FORE8394 was designed to target a wide range of BRAF mutations while sparing wild type forms of RAF. Preclinical studies and clinical trials have shown that its unique mechanism of action effectively inhibits not only the constitutively active BRAFV600 monomers targeted by first-generation RAF inhibitors, but also disrupts constitutively active dimeric BRAF class II mutants, fusions, splice variants and others.
About the program
FORE8394 (formerly PLX-8394) is an investigational, novel, small-molecule, next-generation, orally available selective inhibitor of mutated BRAF. Its inhibition of ERK signaling makes it a strong candidate for the treatment of tumors driven by class I or II BRAF mutations and fusions.
Beyond BRAFV600 mutations
Unlike first-generation RAF inhibitors, FORE8394 does not induce paradoxical activation of the RAF/MEK/ERK pathway. As a “paradox breaker,” FORE8394 could therefore treat acquired resistance to current RAF inhibitors, and, more generally, yield improved safety and more durable efficacy than first-generation RAF inhibitors.
As a BRAF-specific dimer breaker, FORE8394 selectively inhibits ERK signaling in tumors driven by dimeric BRAF mutants, including BRAF fusions and splice variants, as well as BRAFV600 monomers, but spares RAF function in normal cells in which CRAF homodimers can drive signaling.
Information about our ongoing clinical trial
Fore is running a clinical trial open for patients with advanced cancer with BRAF alterations, including both patients with CNS and solid tumors NCT02428712.